Recent Publications
- Lian Liu, Linzhi Zou, Kuan Li, Hanqing Hou, Qun Hu, Shuang Liu, Jie Li, Chenmeng Song, Jiaofeng Chen, Shufeng Wang, Yangzhen Wang, Changri Li, Haibo Du, Jun-Liszt Li, Fangyi Chen, Zhigang Xu, Wenzhi Sun, Qianwen Sun, Wei Xiong✉, Template-independent genome editing in the Pcdh15av-3j mouse, a model of human DFNB23 nonsyndromic deafness. Cell Reports 40, 111061.
- Jie Li, Shuang Liu, Chenmeng Song, Tong Zhu, Zhikai Zhao, Wenzhi Sun, Yi Wang✉, Lei Song✉, Wei Xiong✉, Prestin-mediated frequency selectivity does not cover ultrahigh frequencies in mice. Neuroscience Bulletin 38, 17.
- Yan, Y., Tian, M., Li, M., Zhou, G., Chen, Q., Xu, M., Hu, Y., Luo, W., Guo, X., Zhang, C., Xie, H., Wu, Q. F., Xiong, W.✉, Liu, S.✉, and Guan, J. S.✉ (2022) ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. Neuron 6273 (21) 01090-4.
- Zhang, Y., Lin, G., Wang, Y.✉, Xue, N., Lin, X., Du, T.✉, Xiong, W.✉, and Song, L.✉ (2021) Prestin derived OHC surface area reduction underlies age-related rescaling of frequency place coding. Hear Res, 108406.
- Song, C., Li, J., Liu, S., Hou, H., Zhu, T., Chen, J., Liu, L., Jia, Y., and Xiong, W.✉ (2021) An L1 retrotransposon insertion induced deafness mouse model for studying the development and function of the cochlear stria vascularis. Proc Natl Acad Sci U S A 118 (40) e2107933118.
- Li, J., Liu, S., Song, C., Hu, Q., Zhao, Z., Deng, T., Zou, L., Wang, S., Chen, J., Liu, L., Hou, H., Yuan, K., Zheng, H., Liu, Z., Chen, X., Sun, W., Xiao, B., and Xiong, W.✉ (2021) Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice. Proc Natl Acad Sci U S A 118 (28) e2101207118.
- Du, H., Zou, L., Ren, R., Li, N., Li, J., Wang, Y., Sun, J., Yang, J., Xiong, W.✉, and Xu, Z.✉ (2020). Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J 34, 1136-1149.
- Wang, Y., Su, F., Wang, S., Yang, C., Tian, Y., Yuan, P., Liu, X., Xiong, W.✉, and Zhang, C.✉ (2019) Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging. Bioinformatics 35, 3208-3210.
- Liu, S., Wang, S., Zou, L., Li, J., Song, C., Chen, J., Hu, Q., Liu, L., Huang, P., and Xiong, W.✉ (2019). TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice. Elife 8, e47441.
- Hu, Q., Guo, L., Li, J., Song, C., Yu, L.✉, He, D.Z.Z.✉, and Xiong, W.✉ (2018). Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells. Front Mol Neurosci 11, 326.
- Wang, Y.F., Li, J., Yao, X.R., Li, W., Du, H.B., Tang, M.L., Xiong, W., Chai, R.J., and Xu, Z.G. (2017). Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Front Mol Neurosci 10.
- Chen, J., Zhang, X., Li, J., Song, C., Jia, Y.✉, and Xiong, W.✉ (2016). Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome. Neural Plast 2016, 5836143.
Reviews and Books
- Liu, S., Wang, S., Zou, L., and Xiong, W.✉ (2021) Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity. Cell Mol Life Sci 78, 5083-5094.
- Xiong, W. and Xu, Z. (2018) Mechanotransduction of the Hair Cell. Springer Singapore
Early Publications
- Beurg, M., Xiong, W., Zhao, B., Müller, U., and Fettiplace, R. (2015) Subunit determination of the conductance of hair-cell mechanotransducer channels. Proc Natl Acad Sci U S A112, 1589-1594.
- Xiong, W.✉, T. Wagner, L. Yan, N. Grillet, and U. Müller.✉ (2014). Using Injectoporation to Deliver Genes to Mechanosensory Hair Cells. Nat Protoc 9, no. 10: 2438-49.
- Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F.J., Zhao, B., Johnson, K. R., Kazmierczak, P. and Müller, U., “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells,” Cell 151, no. 6 (2012): p. 1283-95.
- Grillet, N.*, Xiong, W.*, Reynolds, A.*, Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. and Müller, U., “Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells,” Neuron 62, no. 3 (2009): 375-387.
- Schwander, M., Xiong, W., Tokita, J., Lelli, A., Elledge, H. M., Kazmierczak, P., Sczaniecka, A., Kolatkar, A., Wiltshire, T., Kuhn, P., Holt, J. R., Kachar, B., Tarantino, L. and Müller, U., “A Mouse Model for Nonsyndromic Deafness (Dfnb12) Links Hearing Loss to Defects in Tip Links of Mechanosensory Hair Cells,” Proc Natl Acad Sci U S A 106, no. 13 (2009): 5252-5257.