Human patients with hearing impairment have difficulty in perceiving alerts, appreciating music and especially language-based conversation. Our research anticipates gaining a deeper understanding of the fundamental biological principles underlying auditory perception and pathological mechanisms of hearing loss and deafness, which would thus accelerate the development of therapeutic approaches for preventing and treating deafness.
The laboratory is currently focusing on (1) identification of novel deafness genes and characterization of the gene function, (2) mechanisms of cochlear amplification and frequency tuning, and (3) potential therapies to hearing impairment related with genetic mutations, noise, and ageing.
To achieve these goals, (1) mouse models genetically and physiologically mimicking human deafness traits are generated, (2) finest in vitro, ex vivo, and in vivo neurophysiological approaches are developed. These resources will be foundations to explore the mechanisms of sound processing in cochlea and ascending brain stations that is a major long-term goal in the lab.